98.5.7-Case Discussion ACC

Adrenocortical Carcinoma
Fatemeh Rahmani.MD Research  Institute  for  Endocrine  Sciences Shahid  Beheshti  University  of  Medical  Sciences

Questions

    •Clinical presentation of ACC

    •Pathologic work up

    •Staging classification

    •Surgical treatment

    •Adjuvant therapy

    •Follow up

    Clinical Presentation

•For 40% to 60% of patients ,the major presenting complaints are symptoms

   and signs of hormone excess

•Hypercortisolism is the most common presentation (50%–80% ),high cortisol

  saturate the renal HSD11B2 system, resulting in MR activation ,causing HTN

  and hypokalemia

•The second commonly produced hormones are adrenal androgens (40%–60%)

•Concurrent androgen and cortisol production is evident in  half of patients with

  hormonal excess